Division of Child And Adolescents Mental Health

Aim

Conducting research, synthesizing evidence, and raising awareness about child and adolescent mental health and well-being to fill research gaps with practical implications.

Objectives

  • To develop research evidence in the area of child and adolescents mental health
  • To monitor research trials, its conduct and progress
  • To provide training, and building capacity and capability
  • To increase awareness about health and wellbeing of child & adolescents

Workstreams

  • Doing research to find burden of mental health problems in child and adolescents
  • Developing and adapting culturally appropriate evidence based interventions
  • Building capacity of researchers and academic scholars through training and education.
  • Monitoring child and adolescents mental health research studies progress within PILL
  • Monitoring progress of papers and publications within organization
  • Working with local and international partners to strengthen collaboration and conducting awareness raising programs and activities in wider community.
  • Dissemination of study findings.

Role and Functions:

The group will be comprised on academics, researchers, mental health experts and potential members from local and international partner organizations. The chair may invite other potential members to attend meetings when required.

Voting membership

  • Prof. Zainab Zadeh (Chair)
  • Rabia Fahad (Lead)
  • Zahra Nigah
  • Usman Arshad
  • Mueen Abid
  • Mariam Ilyas
  • Sana Azam
  • Amna Khan
  • Mansoor Ahmed
  • Atta-ur-Rehman
  • Madeha Ashfaq

The minimum quorum for a meeting will be 50% of appointed members. No decisions will be taken at any meeting unless a quorum is present. All members will attend at least 70% of the meetings to be part of this group.

2.2 Accountability

Members of this group are accountable to the chair for the roles, functions and workstreams mentioned above in the ToR, and are responsible for meeting organizational standards and policies. This group is accountable to senior management of the organization.

2.3 Minutes & Meeting Papers

All action notes from meetings will be taken by a volunteer member nominated by the chair. Detailed action notes with attachments, will be circulated to all core team members following each meeting.

2.4 Frequency of Meetings

Meeting will be held weekly via online platform.

2.5 Review of ToR

The ToR will be reviewed on an annual basis, or earlier if necessary by the chair and members of the group.

Child and Adolescent

The childhood and adolescent are critical stages of life for mental health development that requires special attention of mental health professionals. Pakistan is a low middle-income country where child and adolescent’s mental health has not received due attention. In Pakistan dilemma is that adult psychiatric and mental health resources are limited while the child and adolescent psychiatric and mental health facilities makes only 0.01%. The situation is same with reference to the availability of child psychologist, and other trained special education professionals. Considering the burden of mental illness, the child and adolescent group from Pakistan Institute of Living and Learning is aiming to address these problems and building capacity in early career researchers. PILL has conducted several interventions based parenting programs to enhance child cognitive, emotional and social development. Presently we are planning for ‘Child and Adolescents Psychiatric Morbidity Survey’ and’ Biopsychosocial origins of depression among adolescents in Pakistan (HOPE-PK)’. PILL has also developed a 6-month certificate course of ‘Child and Adolescent Mental Health Services’ and has successfully completed its first batch recently.

Projects Related to Children and Adolescents

Multicenter RCT to evaluate the clinical and cost effectiveness of a youth culturally adapted manual assisted psychological therapy (Y-CMAP) in Adolescents Pakistani patients with a history of self harm https://pill.org.pk/y-cmap/
Suicide Prevention by Empowering Adolescents in Pakistan (SEPAK): A Feasibility Study for Research Capability and Trial Readiness in Pakistan https://pill.org.pk/campaigns/sepak/
Mindfulness https://pill.org.pk/neuro-dev-child-adolescent/

Projects Related to Children and Adolescents

  • Implementing low-cost Learning through Play (LTP) Plus group Cognitive Behaviour Therapy (CBT) for mothers of young children (0-3 years) in Gadap Town (Roshni-2)
    https://pill.org.pk/parenting-and-maternal-mental-health/
  • Feasibility Trial of Learning through Play (LTP) in My Own Way Plus Cognitive Behaviour Therapy (CBT) as Parent-Based Intervention for Depressed Mothers with children having Intellectual Disability (UMEED)
    https://pill.org.pk/neuro-dev-child-adolescent/
  • Building Resilience Against ViolencE (BRAVE): A Parenting Intervention for mothers and fathers with post-traumatic stress symptoms.

Division Publications

Preliminary Results From a Multi-Centre, Double-Blind, Randomised Placebo Controlled Feasibility Trial of Add-on Sodium Benzoate and/or N-acetylcysteine in Patients With Early Schizophrenia. https://www.biologicalpsychiatryjournal.com/article/S0006-3223(22)00845-9/fulltext

Husain MO, Chaudhry IB, Khan Z, Khoso AB, Kiran T, Bassett P, Husain MI, Upthegrove R, Husain N. Depression and suicidal ideation in schizophrenia spectrum disorder: a cross-sectional study from a lower middle-income country. International journal of psychiatry in clinical practice. 2021 Sep 1;25(3):245-51. https://www.sciencedirect.com/science/article/abs/pii/S0165032722002865

Chaudhry IB, Husain MO, Husain MI, Khoso AB, Buch M, Kiran T, Fu B, Bassett P, Qurashi I, Rahman R, Baig S, Kazmi A, Corsi-Zuelli F, Haddad P, Deakin JFW, Husain N. A randomised clinical trial of methotrexate points to possible efficacy and adaptive immune dysfunction in psychosis. Translational Psychiatry 2020, 2020TP000429R.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410772/

Drake RJ, Husain N, Marshall M, Lewis SW, Tomenson B, Chaudhry IB, Everard L, Singh S, Freemantle N, Fowler D, Jones PB, Amos T, Sharma V, Green CD, Fisher H, Murray RM, Wykes T, Buchan I, Birchwood M. Effect of delaying treatment of first-episode psychosis on symptoms and social outcomes: a longitudinal analysis and modelling study. Lancet Psychiatry July 2020 Vol. 7, 602–610.

https://www.sciencedirect.com/science/article/pii/S2215036620301474

Husain MO, Khoso AB, Renwick L, Kiran T, Saeed S, Lane S, Naeem F, Chaudhry IB, Husain N. Culturally adapted family intervention for schizophrenia in Pakistan: a feasibility study. International Journal of Psychiatry in Clinical Practice 2020, DOI:

10.1080/13651501.2020.1819332. https://www.tandfonline.com/doi/abs/10.1080/13651501.2020.1819332

Deakin B, Suckling J, Dazzan P, Joyce E, Lawrie SM, Upthegrove R, Husain N, Chaudhry IB, Dunn G, Jones PB, Lisiecka-Ford D. Minocycline for negative symptoms of schizophrenia and possible mechanistic actions: the BeneMin RCT. Efficacy and Mechanism Evaluation. 2019;6(7):1-66.

https://discovery.ucl.ac.uk/id/eprint/10084127/

Deakin B, Suckling J, Barnes TRE, Byrne K, Chaudhry IB, Dazzan P, Drake RJ,Giordano A, Husain N, et al. The benefit of minocycline on negative symptoms of schizophrenia in patients with recent-onset psychosis (BeneMin): a randomised, double-blind, placebo-controlled trial. Lancet Psychiatry. 2018 Nov;5(11):885-894.

https://www.sciencedirect.com/science/article/pii/S2215036618303456

Husain MO, Chaudhry IB, Thomasson R, Kiran T, Bassett P, Husain MI, Naeem F, Husain N. Cognitive function in early psychosis patients from a lower middle-income country. Int J Psychiatry Clin Pract. 2018 Mar;22(1):13-18.

https://www.tandfonline.com/doi/abs/10.1080/13651501.2017.1341987

Husain MO, Chaudhry IB, Mehmood N, ur Rehman R, Kazmi A, Hamirani M, Kiran T, Bukhsh A, Bassett P, Husain MI, Naeem F. Pilot randomised controlled trial of culturally adapted cognitive behavior therapy for psychosis (CaCBTp) in Pakistan. BMC health services research. 2017 Dec;17(1):808.

https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-017-2740-z

Reeder FD, Husain N, Rhouma A, Haddad PM, Munshi T, Naeem F, Khachatryan D, Chaudhry IB. The relationship between childhood trauma and adult psychosis in a UK Early Intervention Service: results of a retrospective case note study. Neuropsychiatric Disease and Treatment 2017 Feb 8;13:269-273.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308563/

Husain N, Gire N, Kelly J, Duxbury J, McKeown M, Riley M, Taylor CD, Taylor PJ, Emsley R, Farooq S, Caton N, Naeem F, Kingdon D, Chaudhry IB. TechCare: mobile assessment and therapy for psychosis – an intervention for clients in the Early Intervention Service: A feasibility study protocol. SAGE Open Med. 2016 Oct 18;4:2050312116669613.
https://journals.sagepub.com/doi/full/10.1177/2050312116669613

Lisiecka DM, Suckling J, Barnes TRE, Chaudhry IB, Dazzan P, Husain N, Jones PB, Joyce E, Lawrie SM, Upthegrove R and Deakin B. The benefit of minocycline on negative symptoms in early-phase psychosis in addition to standard care – extent and mechanism (BeneMin): study protocol for a randomized controlled trial. Trials 2015 Mar 2;16 (1):71.
https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-015-0580-x

Marshall M, Husain N, Bork N, Chaudhry IB, Lester HE, Everard L, Singh SP, Freemantle N, Sharma V, Jones PB, Fowler D, Amos T, Tomenson B, Birchwood M. Impact of early intervention services on duration of untreated psychosis: data from the National EDEN prospective cohort study. Schizophrenia Research 2014 Oct; 159(1):1-6.

https://www.sciencedirect.com/science/article/abs/pii/S0920996414003624

Adam U, Husain N, Haddad P, Munshi T, Tariq F, Naeem F, Chaudhry IB. Tardive dyskinesia in a South Asian Population with first episode psychosis (FEP) treated with antipsychotics. Neuropsychiatric Disease and Treatment 2014 Oct 14;10: 1953-9.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206401/

Khan F, Rhouma A, Siddiq H, Gire N, Chaudhry IB, Husain N. Early Intervention in Psychosis (EIP) Services, UK: A Critical Analysis Of The Evidence. Journal of Pakistan Psychiatric Society 2013 10 (1): 8-13.

https://pesquisa.bvsalud.org/portal/resource/pt/emr-147867

Haddad PM, Das A, Keyhani S, Chaudhry IB. Antipsychotic drugs and extrapyramidal side-effects in first episode psychosis: a systematic review of head-head comparisons. Journal of Psychopharmacology 2012; 26: 15-26.

https://journals.sagepub.com/doi/full/10.1177/0269881111424929

Haddad PM, Chaudhry IB. Challenges in management of early psychosis. Journal of Psychopharmacology 2012; 26: 5-6.

https://journals.sagepub.com/doi/full/10.1177/0269881111405365

2022

Preliminary Results From a Multi-Centre, Double-Blind, Randomised Placebo Controlled Feasibility Trial of Add-on Sodium Benzoate and/or N-acetylcysteine in Patients With Early Schizophrenia. https://www.biologicalpsychiatryjournal.com/article/S0006-3223(22)00845-9/fulltext

2021

Husain MO, Chaudhry IB, Khan Z, Khoso AB, Kiran T, Bassett P, Husain MI, Upthegrove R, Husain N. Depression and suicidal ideation in schizophrenia spectrum disorder: a cross-sectional study from a lower middle-income country. International journal of psychiatry in clinical practice. 2021 Sep 1;25(3):245-51. https://www.sciencedirect.com/science/article/abs/pii/S0165032722002865

2020

Chaudhry IB, Husain MO, Husain MI, Khoso AB, Buch M, Kiran T, Fu B, Bassett P, Qurashi I, Rahman R, Baig S, Kazmi A, Corsi-Zuelli F, Haddad P, Deakin JFW, Husain N. A randomised clinical trial of methotrexate points to possible efficacy and adaptive immune dysfunction in psychosis. Translational Psychiatry 2020, 2020TP000429R.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8410772/

Drake RJ, Husain N, Marshall M, Lewis SW, Tomenson B, Chaudhry IB, Everard L, Singh S, Freemantle N, Fowler D, Jones PB, Amos T, Sharma V, Green CD, Fisher H, Murray RM, Wykes T, Buchan I, Birchwood M. Effect of delaying treatment of first-episode psychosis on symptoms and social outcomes: a longitudinal analysis and modelling study. Lancet Psychiatry July 2020 Vol. 7, 602–610.

https://www.sciencedirect.com/science/article/pii/S2215036620301474

Husain MO, Khoso AB, Renwick L, Kiran T, Saeed S, Lane S, Naeem F, Chaudhry IB, Husain N. Culturally adapted family intervention for schizophrenia in Pakistan: a feasibility study. International Journal of Psychiatry in Clinical Practice 2020, DOI:

10.1080/13651501.2020.1819332. https://www.tandfonline.com/doi/abs/10.1080/13651501.2020.1819332

2019

Deakin B, Suckling J, Dazzan P, Joyce E, Lawrie SM, Upthegrove R, Husain N, Chaudhry IB, Dunn G, Jones PB, Lisiecka-Ford D. Minocycline for negative symptoms of schizophrenia and possible mechanistic actions: the BeneMin RCT. Efficacy and Mechanism Evaluation. 2019;6(7):1-66.

https://discovery.ucl.ac.uk/id/eprint/10084127/

2018

Deakin B, Suckling J, Barnes TRE, Byrne K, Chaudhry IB, Dazzan P, Drake RJ,Giordano A, Husain N, et al. The benefit of minocycline on negative symptoms of schizophrenia in patients with recent-onset psychosis (BeneMin): a randomised, double-blind, placebo-controlled trial. Lancet Psychiatry. 2018 Nov;5(11):885-894.

https://www.sciencedirect.com/science/article/pii/S2215036618303456

Husain MO, Chaudhry IB, Thomasson R, Kiran T, Bassett P, Husain MI, Naeem F, Husain N. Cognitive function in early psychosis patients from a lower middle-income country. Int J Psychiatry Clin Pract. 2018 Mar;22(1):13-18.

https://www.tandfonline.com/doi/abs/10.1080/13651501.2017.1341987

2017

Husain MO, Chaudhry IB, Mehmood N, ur Rehman R, Kazmi A, Hamirani M, Kiran T, Bukhsh A, Bassett P, Husain MI, Naeem F. Pilot randomised controlled trial of culturally adapted cognitive behavior therapy for psychosis (CaCBTp) in Pakistan. BMC health services research. 2017 Dec;17(1):808.

https://bmchealthservres.biomedcentral.com/articles/10.1186/s12913-017-2740-z

Reeder FD, Husain N, Rhouma A, Haddad PM, Munshi T, Naeem F, Khachatryan D, Chaudhry IB. The relationship between childhood trauma and adult psychosis in a UK Early Intervention Service: results of a retrospective case note study. Neuropsychiatric Disease and Treatment 2017 Feb 8;13:269-273.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308563/

2016

Husain N, Gire N, Kelly J, Duxbury J, McKeown M, Riley M, Taylor CD, Taylor PJ, Emsley R, Farooq S, Caton N, Naeem F, Kingdon D, Chaudhry IB. TechCare: mobile assessment and therapy for psychosis – an intervention for clients in the Early Intervention Service: A feasibility study protocol. SAGE Open Med. 2016 Oct 18;4:2050312116669613.
https://journals.sagepub.com/doi/full/10.1177/2050312116669613

2015

Lisiecka DM, Suckling J, Barnes TRE, Chaudhry IB, Dazzan P, Husain N, Jones PB, Joyce E, Lawrie SM, Upthegrove R and Deakin B. The benefit of minocycline on negative symptoms in early-phase psychosis in addition to standard care – extent and mechanism (BeneMin): study protocol for a randomized controlled trial. Trials 2015 Mar 2;16 (1):71.
https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-015-0580-x

2014

Marshall M, Husain N, Bork N, Chaudhry IB, Lester HE, Everard L, Singh SP, Freemantle N, Sharma V, Jones PB, Fowler D, Amos T, Tomenson B, Birchwood M. Impact of early intervention services on duration of untreated psychosis: data from the National EDEN prospective cohort study. Schizophrenia Research 2014 Oct; 159(1):1-6.

https://www.sciencedirect.com/science/article/abs/pii/S0920996414003624

Adam U, Husain N, Haddad P, Munshi T, Tariq F, Naeem F, Chaudhry IB. Tardive dyskinesia in a South Asian Population with first episode psychosis (FEP) treated with antipsychotics. Neuropsychiatric Disease and Treatment 2014 Oct 14;10: 1953-9.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206401/

2013

Khan F, Rhouma A, Siddiq H, Gire N, Chaudhry IB, Husain N. Early Intervention in Psychosis (EIP) Services, UK: A Critical Analysis Of The Evidence. Journal of Pakistan Psychiatric Society 2013 10 (1): 8-13.

https://pesquisa.bvsalud.org/portal/resource/pt/emr-147867

2012

Haddad PM, Das A, Keyhani S, Chaudhry IB. Antipsychotic drugs and extrapyramidal side-effects in first episode psychosis: a systematic review of head-head comparisons. Journal of Psychopharmacology 2012; 26: 15-26.

https://journals.sagepub.com/doi/full/10.1177/0269881111424929

Haddad PM, Chaudhry IB. Challenges in management of early psychosis. Journal of Psychopharmacology 2012; 26: 5-6.

https://journals.sagepub.com/doi/full/10.1177/0269881111405365

Some Beautiful Highlights

Gallery

International Collaborators

Prof. Nusrat Husain

Dr. Inti Qureshi

Dr. Omair Husain

Mr. Madi